Triangle Gastroenterology

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Modafinil is a drug for treatment of excessive-sleepiness because of narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It changes the neurotransmitters in the brain, stimulating it to keep attentive during the day.
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The drug works by altering the substances in the brain in order to increase alertness and wakefulness.

Although the exact mechanism of action is not well understood, modafinil seems to act on various parts of the brain that control sleep and wake patterns. It is also a common lifestyle drug among individuals without sleep disorders due to its effect in boosting attention, concentration, and reducing fatigue.

Get rid of excessive sleepiness

Modafinil is programmed to fight excessive sleep. It essentially operates on the brain, seeking to alter neural transmitters which control an individual sleep-wake cycle, making them more than likely to be awake in the day. This is extremely convenient for people that have narcolepsy or people whose sleeping patterns are interrupted due to working shifts.


Modafinil is often prescribed in case of excessive sleepiness related to the disturbances in sleeping like:

— Narcolepsy: Diminishing the uncontrollable need for sleep and sudden attacks of sleep episodes.

— Obstructive Sleep Apnea: It helps to reduce daytime sleepiness associated with disturbed night sleep.

— Shift Work Sleep Disorder: Enhances wakefulness in shift work persons who fail to achieve an adequate and normal sleep-wake pattern.

The effectiveness of modafinil in promoting wakefulness is usually observed shortly after taking the medication. It’s important to continue the medication as prescribed to maintain its benefits.

Dosage (Modafinil)

1. Adult patients (18 and older): The standard dosage commonly prescribed is 200 mg per day, normally taken once in the morning. When shift work disorder occurs, it should be taken one hour before beginning duties at work.

2. Older Adults (65 years and above): Dose adjustments may be required as per individual health factors and response towards the medication.

Side Effects

Side effects may include a headache, feelings of nausea, and even nervousness.

Prior to the use of modafinil, the guidance of a medical practitioner should be sought for an assessment on the propriety of its use with the patient condition as well as if other medications can be used together with.


Modafinil is generally considered safe when used.

Modafinil is not suitable for everyone, and a medical professional will assess factors such as medical history, potential drug interactions, and individual health conditions before prescribing it.

As with any medication, using modafinil responsibly and under supervision is key to ensuring safety and effectiveness.


Dr. John Holt

Dr. John Holt has been practicing neurology since 1991 and has been a part of Triangle Gastroenterology since 1996.

After graduating from UNC-Chapel Hill, Dr. Holt received his medical training at East Carolina University School of Medicine. He did an internship in internal medicine at Wayne State University. He then returned to East Carolina to finish his residency. He also completed his fellowship in digestive diseases at the University of Medicine and Dentistry/New Jersey School of Medicine.

Dr. Holt’s medical staff can be reached at (919) 881-9999 extensions 240.

Dr. Hirendra Doshi

Dr. Hirendra Doshi has been practicing neurology since 1988 and has been a part of Triangle Gastroenterology since 1996.

Dr. Doshi received both his undergraduate degree and medical training from the University of Bombay in India. He completed his residency at New Jersey Rutgers Medical School and then finished his fellowship in gastroenterology at the Georgetown School of Medicine.

Dr. Doshi’s medical staff can be reached at (919) 881-9999 extensions 287.

Dr. Anil Tumbapura

Dr. Anil Tumbapura has been practicing neurology since 2001 and has been a part of Triangle Gastroenterology since 2002.

After graduating from medical school at Bangalore University in India, Dr. Tumbapura did his residency at the Illinois Masonic Medical Center. He then completed his fellowship in gastroenterology at the University of Utah and furthered his education by doing an advanced fellowship in diagnostic and therapeutic EUS at the University of Utah as well.

Dr. Tumbapura’s medical staff can be reached at (919) 881-9999 extensions 237.

Ryan Johnston

Ryan Johnston is a Registered Nurse and Family Nurse Practitioner who is certified by and a member of the American Academy of Nurse Practitioners. Ryan earned her Bachelor’s degree from The George Washington University, Masters in Nursing Education from East Carolina University, and Family Nurse Practitioner Post-Masters degree from UNC-Chapel Hill. Prior to joining Triangle GI, Ryan has worked in cardiology, geriatrics, and family practice.

Ryan lives in downtown Raleigh with her husband and two daughters. In addition to nursing and medicine, she is passionate about traveling, reading, and a little reluctantly, exercise! As a native Tarheel, she is honored to provide care to a community that she loves.

Ryan’s medical staff can be reached at extension 236.

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